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KMID : 0882420120830010107
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Korean Journal of Medicine
2012 Volume.83 No. 1 p.107 ~ p.112
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A Case of POEMS Syndrome Associated with Sarcoidosis
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Yoon Hwan
Kang Byung-Ju
Kim Woo-Sung
Kim Dong-Soon
Song Jin-Woo
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Abstract
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POEMS syndrome is a monoclonal plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Pulmonary manifestations of POEMS syndrome are common, with frequent symptomatic and asymptomatic respiratory involvement on presentation. However, there have been no reported cases of concomitant sarcoidosis and POEMS syndrome. We treated a 55-year-old woman who presented with dyspnea and bilateral lower leg pitting edema. She had been diagnosed with sarcoidosis 4 years earlier. We reassessed the patient meticulously and found polyneuropathy, IgG lambda type monoclonal gammopathy, lymphadenopathy, hepatosplenomegaly, hypothyroidism, hypertrichosis, and pleural and pericardial effusions, all of which led us to diagnose POEMS syndrome. Immunosuppression with high-dose dexamethasone led to clinical and radiological improvement.
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KEYWORD
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Lung disease, POEMS syndrome, Sarcoidosis
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